“I am on dialysis, but why do I still have high creatinine level?” Many patients undergoing dialysis have this kind of doubt. Here we will explain it in detail.
Firstly, you should know why you have to go on dialysis and what the function of this treatment is.
No matter what caused your kidney disease and which kind it belongs to, the result is the same: your kidneys will gradually lose their function and failed to finish their task. This is called end-stage renal disease (ESRD). Generally, the options for this stage is either dialysis or kidney transplant. Here we just talk about dialysis.
How does dialysis help to treat your kidney failure? Actually, dialysis is not “treating” your kidney failure at all—it just take the place of the kidneys to perform the functions that should have been done by the kidneys. When the kidneys have lost most of their functions, dialysis is needed to help your kidneys to filter your blood and clean the metabolic wastes.
Secondly, why you still have high creatinine level after the dialysis treatment?
We have explained that dialysis is just a replacement therapy of kidney failure. You have to do dialysis regularly because your body is continuously producing metabolic wastes, which must be cleared out from time to time. Creatinine is just one of the metabolic products.
Creatinine is the waste product of protein metabolism. Derived from creatine and synthesized in liver, kidneys and pancreas and stored in muscle tissue. Creatinine is released into the extracellular fluid and excreted through the kidneys. Creatinine is filtered by the glomeruli and NOT reabsorbed. When kidneys are working properly, serum creatinine level is low but with renal function impaired, creatinine level increases. If half of nephrons are damaged then serum creatinine level rises to about double.
During dialysis, your creatinine would have a fluctuation. When you have just finished the dialysis, your creatinine level would go down because creatinine in your blood has been cleaned out by the dialysis. Therefore, creatinine does not really go down during dialysis (meaning while on dialysis not actually while on the machine during a run). Creatinine doesn't go down basically because labs are usually taken before a dialysis session so you can get an idea of where the body is at; if it was taken right after a dialysis session it would be artificially lower, because the toxins would be removed. Anyway since the creatinine is just a measure of the toxins in the blood and the kidneys aren’t doing their job it will remain high, reflecting the fact that toxins are building up between dialysis sessions(and hence the need for dialysis). Once on dialysis the creatinine measure is mostly irrelevant anyway since the renal function is gone anyway.
Another factor is that different kinds of dialysis have different effect. The two basic types of dialysis are hemodialysis and peritoneal dialysis. Compared with hemodialysis, peritoneal dialysis can lower the creatinine to a smaller degree. That is to say, your creatinine can be lowered by peritoneal dialysis not as much as hemodialysis.
Normal creatinine level (for reference):
Men = 0.6~1.5 mg/dL
Women = 0.6~1.1 mg/dL
Pregnancy = reduced in children = 0.2~1.0 mg/dL
That’s all for high creatinine level in patients undergoing dialysis.
Showing posts with label Dialysis. Show all posts
Showing posts with label Dialysis. Show all posts
Saturday, 22 October 2011
Tuesday, 18 October 2011
Is Dialysis Inevitable for Diabetics
Diabetes Mellitus is always called Silent Killer due to its severity and latent complications. Once someone gets Diabetes, various complications are just around the corner. Among them, Diabetic Nephropathy is always attached much importance to, and finally the dialysis become inevitable if there is no effective treatment in time. Is dialysis really inevitable for Diabetes? We get some knowledge of Diabetes and Diabetic Nephropathy first.
Diabetes is characterized by the retention of blood glucose in human body which is aroused by the decreased function of pancreas and the insulin resistance. During the course, kidneys are always involved in. When there are some pathological changes in kidney, we can find the basilar membrane become broad, accompanied by proliferation of mesangial cells and the hyperplasia of extracellular matrixes in glomeruli, and also the broadening and nodosity of glomerular capsules.
There is no exact reason to explain the involvement of kidney during Diabetes. However, according to the study of pathology, we can illustrate it in the following way.
The key reason can be abnormal hemodynamics in kidneys. When the level of blood glucose is higher, the glomeruli will be in a situation of high perfusion and high filtration, so the pressure in capillaries will rise and epithelial cells in glomeruli will drop as well. Also, the type IV collagen in basilar membrane become more, so the mesangial area broadens and glomeruli are sclerosed. Meanwhile, excessive protein accumulates in basilar membrane, promoting the proliferation of extracellular matrixes. What's more, the genetic history and high blood pressure are the influencing factors for diabetics to develop Diabetic Nephropathy.
Once the kidneys are involved in the Diabetes, the course of it can be divided into five stages. In the early stages, say, the stage 1, 2, and 3, The Glomerular Filtration Rate (GFR) is at first higher and become normal later then; the disease condition can be reversed if effective treatment can be provided, and if no, more than 90% of the suffers can become the really obvious Diabetic Nephropathy. Then, it progresses into clinical Diabetic Nephropathy during which the GFR decreases accompanied by Hypertension in most cases, and If the blood pressure cannot be controlled well, the GFR will deteriorate rapidly, so that the suffers will develop Kidney Failure within 5-8 years, that is to say, in the end stage of Diabetic Nephropathy. The GFR decreases to be less than 10ml/min; the levels of urea nitrogen and creatinine increase; edema and Hypertension aggravate further, and Hypoproteinemia will appear. What's worse, retinal changes and nerve changes will come together with the Diabetic Nephropathy in many cases. Generally speaking, when the patient is in his stage 4, the serum creatinine will be higher than 400umol/L. In stage 5, the level of creatinine and blood urea nitrogen (BUN) rises obviously, and when the creatinine is as high as 700umol/L, dialysis is inevitably necessary because almost all the kidney functions are lost already.
Here is the summarized introduction from which you can know how the Diabetes develops into Diabetic Nephropathy, and how the dialysis become inevitable. In the end stage of Diabetic Nephropathy, kidneys lose most functions so all the wastes in human body need to be excreted outside with the help of dialysis. From all those mentioned above, we can know the importance of effective and timely treatment for Diabetes. Only when the condition is controlled in the early stages, can the progress be decelerated. Also, when effective treatment can be provided, the dialysis can be avoided thereby.
Diabetes is characterized by the retention of blood glucose in human body which is aroused by the decreased function of pancreas and the insulin resistance. During the course, kidneys are always involved in. When there are some pathological changes in kidney, we can find the basilar membrane become broad, accompanied by proliferation of mesangial cells and the hyperplasia of extracellular matrixes in glomeruli, and also the broadening and nodosity of glomerular capsules.
There is no exact reason to explain the involvement of kidney during Diabetes. However, according to the study of pathology, we can illustrate it in the following way.
The key reason can be abnormal hemodynamics in kidneys. When the level of blood glucose is higher, the glomeruli will be in a situation of high perfusion and high filtration, so the pressure in capillaries will rise and epithelial cells in glomeruli will drop as well. Also, the type IV collagen in basilar membrane become more, so the mesangial area broadens and glomeruli are sclerosed. Meanwhile, excessive protein accumulates in basilar membrane, promoting the proliferation of extracellular matrixes. What's more, the genetic history and high blood pressure are the influencing factors for diabetics to develop Diabetic Nephropathy.
Once the kidneys are involved in the Diabetes, the course of it can be divided into five stages. In the early stages, say, the stage 1, 2, and 3, The Glomerular Filtration Rate (GFR) is at first higher and become normal later then; the disease condition can be reversed if effective treatment can be provided, and if no, more than 90% of the suffers can become the really obvious Diabetic Nephropathy. Then, it progresses into clinical Diabetic Nephropathy during which the GFR decreases accompanied by Hypertension in most cases, and If the blood pressure cannot be controlled well, the GFR will deteriorate rapidly, so that the suffers will develop Kidney Failure within 5-8 years, that is to say, in the end stage of Diabetic Nephropathy. The GFR decreases to be less than 10ml/min; the levels of urea nitrogen and creatinine increase; edema and Hypertension aggravate further, and Hypoproteinemia will appear. What's worse, retinal changes and nerve changes will come together with the Diabetic Nephropathy in many cases. Generally speaking, when the patient is in his stage 4, the serum creatinine will be higher than 400umol/L. In stage 5, the level of creatinine and blood urea nitrogen (BUN) rises obviously, and when the creatinine is as high as 700umol/L, dialysis is inevitably necessary because almost all the kidney functions are lost already.
Here is the summarized introduction from which you can know how the Diabetes develops into Diabetic Nephropathy, and how the dialysis become inevitable. In the end stage of Diabetic Nephropathy, kidneys lose most functions so all the wastes in human body need to be excreted outside with the help of dialysis. From all those mentioned above, we can know the importance of effective and timely treatment for Diabetes. Only when the condition is controlled in the early stages, can the progress be decelerated. Also, when effective treatment can be provided, the dialysis can be avoided thereby.
Thursday, 28 July 2011
Dialysis is addict or not
You may be recommended to start dialysis by your doctor; or you have heard dialysis many times and think about starting it. Whatever, you are curious whether you will be addicted to dialysis once you start it. In other words, you are worried that you can’t stop dialysis once you receive it. After reading this article, you will get the answer.
Dialysis is often called ‘artificial kidney’ in some countries. This is because dialysis can replace the kidneys in excreting metabolic waste and excess water in the blood, preventing the body from being damaged by the toxins. In this view, dialysis could replace the kidneys. But the kidneys also have the ability of secreting many kinds of hormone which play important role in metabolism. And dialysis can do nothing about this. Hence, we can conclude that dialysis is a way to help you clean up your blood.
When you receive dialysis, how are your kidneys? Can they be treated by dialysis? No. Your kidneys are still continuously damaged. Extra cellular matrixes of the renal intrinsic cells proliferate, resulting that your kidneys on the way of fibrosis. What’s more, these matrixes will damage the healthy renal intrinsic cells. Eventually, the kidneys become fibrosis and they loss all functions. Dialysis can do nothing to prevent this happening. On the way of renal fibrosis, your kidneys become worse and worse. So you have to perform dialysis more frequently. Just like addicting to drugs, you cannot get rid of it.
Nonetheless, some people can get rid of it. There are various reasons. But what matter are treatment and patients’ condition. If you receive other therapy to treat your damaged kidneys during dialysis, your kidneys may get better, and to some degree, you can stop dialysis.
Generally, doctors in some countries will not give patients who are on dialysis other therapies to repair the kidneys, or they don’t have better way to help rebuild functions of the kidneys.
Dialysis is often called ‘artificial kidney’ in some countries. This is because dialysis can replace the kidneys in excreting metabolic waste and excess water in the blood, preventing the body from being damaged by the toxins. In this view, dialysis could replace the kidneys. But the kidneys also have the ability of secreting many kinds of hormone which play important role in metabolism. And dialysis can do nothing about this. Hence, we can conclude that dialysis is a way to help you clean up your blood.
When you receive dialysis, how are your kidneys? Can they be treated by dialysis? No. Your kidneys are still continuously damaged. Extra cellular matrixes of the renal intrinsic cells proliferate, resulting that your kidneys on the way of fibrosis. What’s more, these matrixes will damage the healthy renal intrinsic cells. Eventually, the kidneys become fibrosis and they loss all functions. Dialysis can do nothing to prevent this happening. On the way of renal fibrosis, your kidneys become worse and worse. So you have to perform dialysis more frequently. Just like addicting to drugs, you cannot get rid of it.
Nonetheless, some people can get rid of it. There are various reasons. But what matter are treatment and patients’ condition. If you receive other therapy to treat your damaged kidneys during dialysis, your kidneys may get better, and to some degree, you can stop dialysis.
Generally, doctors in some countries will not give patients who are on dialysis other therapies to repair the kidneys, or they don’t have better way to help rebuild functions of the kidneys.
Saturday, 16 July 2011
Dialysis is not a Good Way to Treat Kidney Disease
In medicine, dialysis is a process for removing waste and excess water from the blood, and is primarily used to provide an artificial replacementfor lost kidney function in people with renal failure. Dialysis may be used for those with an acute disturbance in kidney function or for those with progressive but chronically worsening kidney function–a state known as chronic kidney disease stage 5 . The latter form may develop over months or years, but in contrast to acute kidney injury is not usually reversible, and dialysis is regarded as a "holding measure" until a renal transplant can be performed, or sometimes as the only supportive measure in those for whom a transplant would be inappropriate.
Does your doctor recommend dialysis to you? Have you yet mode the decision to begin dialysis? Whether your answer is yes or not, it is quite necessary for you to read this article and get to know the troublesome disadvantages of dialysis.
Firstly, dialysis cannot cure kidney disease. A healthy kidney mainly has three functions. It maintains the body's internal equilibrium of water and minerals (sodium, potassium, chloride, calcium, phosphorus, magnesium). It also purifies the blood by discharging harmful substances out of the body. Besides, it functions as a part of the endocrine system producing erythropoietin which is involved in the production of red blood cells and calcitriol which plays a role in bone formation. Dialysis could replace a kidney just in terms of the first two functions, but it cannot produce the indispensable hormone as a kidney does. Hence, dialysis cannot cure kidney disease. What’s more, once you start dialysis, your kidney will do less and less work, and even to the degree that it doesn’t work any longer and then you have to do dialysis in your whole life.
Secondly, dialysis has some side effects. You may be uncomfortable when needles are put into the fistula or graft. You may have a headache and feel sick to you stomach, vomit and cramps during dialysis. The major problem is that you may risk of infection at the entry point when the catheter entering the abdomen, no matter which kind of dialysis you do, hemodialysis or peritoneal dialysis.
Finally, once you begin dialysis, your time table will become less flexible. When choosing hemodialysis, you will be required to adhere to a specific schedule and travel to the dialysis unit. And each hemodialysis treatment usually lasts about four hours and is done three times per week. As for peritoneal dialysis, although it could be performed at home, it must be done every day of the week.
It concludes from the above that dialysis is not a good way to treat kidney disease. Then is there any effective ways of treating kidney disease? Yes. They are Micro-Chinese Medicine Therapy and Stem Cell Transplant. Clinical practices in Shijiazhuang Kidney Disease Hospital have proven that combination of this two therapies have fabulous effects in the treatment of kidney disease. Both of them have no side effects and takes less time than dialysis, Micro-Chinese Medicine just takes forty five minutes every time while Stem Cell Transplant merely one hour every time and three times in total.
Micro-Chinese Medicine processing technology is micronizing the Chinese medicine molecules of micron-sized diameter into one thousandths smaller granules by using powerful ultrasonic cavitations. And then make the effective ingredients of the Chinese medicine overflow fully; therefore it can improve traditional Chinese medicine penetrability so that it can infiltrate into lesion rapidly and change the valence bond structure. Moreover, after the medicine penetrability is improved, ingredients will not roam to other organs by crossing the kidney. The characteristic of traditional Chinese medicine is certain medicine come into certain meridians. The medicine enters into the renal channel will not wander, which is the foundation of the traditional Chinese medicine.Without the micro process of the traditional Chinese medicine, many effective medicine ingredients are devoured by the phagocyte due to the big medicine particle. While the microsized medicine cheat the phagocyte and enter the kidney.
The active ingredients of Chinese Medicine after microsized can smoothly enter the human body and achieve lesions by using various channels. At present, the Micro Penetration is mainly through the following channels into the renal lesion.
It can directly arrive at lesion through the renal skin of waist back under the action of micro osmotic instrument by means of permeability and selective targeted function.
Entering the blood through the waist back or digestive tract with the blood circulation targeted for the renal lesion.
Through the back meridian system, the medicine can be targeted into the human body and settled in the lesion.
The Micro-Chinese Medicine Osmotherapy made a breakthrough for the medical profession. Currently, it is an original treatment for the kidney disease and Uraemia, and it explores a new way of thinking for the treatment of other chronic complicated.
Does your doctor recommend dialysis to you? Have you yet mode the decision to begin dialysis? Whether your answer is yes or not, it is quite necessary for you to read this article and get to know the troublesome disadvantages of dialysis.
Firstly, dialysis cannot cure kidney disease. A healthy kidney mainly has three functions. It maintains the body's internal equilibrium of water and minerals (sodium, potassium, chloride, calcium, phosphorus, magnesium). It also purifies the blood by discharging harmful substances out of the body. Besides, it functions as a part of the endocrine system producing erythropoietin which is involved in the production of red blood cells and calcitriol which plays a role in bone formation. Dialysis could replace a kidney just in terms of the first two functions, but it cannot produce the indispensable hormone as a kidney does. Hence, dialysis cannot cure kidney disease. What’s more, once you start dialysis, your kidney will do less and less work, and even to the degree that it doesn’t work any longer and then you have to do dialysis in your whole life.
Secondly, dialysis has some side effects. You may be uncomfortable when needles are put into the fistula or graft. You may have a headache and feel sick to you stomach, vomit and cramps during dialysis. The major problem is that you may risk of infection at the entry point when the catheter entering the abdomen, no matter which kind of dialysis you do, hemodialysis or peritoneal dialysis.
Finally, once you begin dialysis, your time table will become less flexible. When choosing hemodialysis, you will be required to adhere to a specific schedule and travel to the dialysis unit. And each hemodialysis treatment usually lasts about four hours and is done three times per week. As for peritoneal dialysis, although it could be performed at home, it must be done every day of the week.
It concludes from the above that dialysis is not a good way to treat kidney disease. Then is there any effective ways of treating kidney disease? Yes. They are Micro-Chinese Medicine Therapy and Stem Cell Transplant. Clinical practices in Shijiazhuang Kidney Disease Hospital have proven that combination of this two therapies have fabulous effects in the treatment of kidney disease. Both of them have no side effects and takes less time than dialysis, Micro-Chinese Medicine just takes forty five minutes every time while Stem Cell Transplant merely one hour every time and three times in total.
Micro-Chinese Medicine processing technology is micronizing the Chinese medicine molecules of micron-sized diameter into one thousandths smaller granules by using powerful ultrasonic cavitations. And then make the effective ingredients of the Chinese medicine overflow fully; therefore it can improve traditional Chinese medicine penetrability so that it can infiltrate into lesion rapidly and change the valence bond structure. Moreover, after the medicine penetrability is improved, ingredients will not roam to other organs by crossing the kidney. The characteristic of traditional Chinese medicine is certain medicine come into certain meridians. The medicine enters into the renal channel will not wander, which is the foundation of the traditional Chinese medicine.Without the micro process of the traditional Chinese medicine, many effective medicine ingredients are devoured by the phagocyte due to the big medicine particle. While the microsized medicine cheat the phagocyte and enter the kidney.
The active ingredients of Chinese Medicine after microsized can smoothly enter the human body and achieve lesions by using various channels. At present, the Micro Penetration is mainly through the following channels into the renal lesion.
It can directly arrive at lesion through the renal skin of waist back under the action of micro osmotic instrument by means of permeability and selective targeted function.
Entering the blood through the waist back or digestive tract with the blood circulation targeted for the renal lesion.
Through the back meridian system, the medicine can be targeted into the human body and settled in the lesion.
The Micro-Chinese Medicine Osmotherapy made a breakthrough for the medical profession. Currently, it is an original treatment for the kidney disease and Uraemia, and it explores a new way of thinking for the treatment of other chronic complicated.
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