An Introduction of Uremia

The function of kidney screens out harmful ingredients in blood; at the same time, stays the useful ingredients, such as cells ingredients, fat and protein. Under the situation of renal failure, the harmful ingredients in blood can not be ejected from body, thus damages the body issue and organ. This is uremia.
It is known that uremia is the final stage of renal failure and also a chronic difficulty and complicated case. All kinds of kidney disease will change to uremia sooner or later if not controlled in time. Chronic renal nephritis has not been effectively controlled; it may start renal fibrosis, and if the course of renal fibrosis has not been blocked, renal will lose it function gradually. Therefore uremia is the final appearance of renal fibrosis. Blocking the course of renal fibrosis is the initiative to prevent or to cure uremia.
When normal nephrons are less than 10% there will be serious metabolic acidosis, and a series of symptoms appear in heart, brain, or other parts. This is end stage renal failure, namely uremic stage. This period is called late stromatic prosphase. In this period, nephrons are all in hardening time, and all cells are in hardening procedure. This period is also called stromatic independent prosphase. The synthetic and hyperplasia of extracellular matrix are both autonomic, not depend on external factors.
General public know it is because the worse of kidney disease. But the exact reason is renal fibrosis. Tessence of chronic kidney disease changing to renal failure or uremia is the loss of effective nephrons and the progressive decline of renal function. There is a direct, inevitable relationship between renal failure, uremia and renal fibrosis. Accurately speaking, the course of renal failure and uremia is the progressive course of renal fibrosis. More, renal failure and uremia are both functional expressions when the renal fibrosis is at a proportion of 50% or higher. So blocking the course of renal fibrosis is very important, especially for controlling the development of the illness condition and preventing kidney disease change to uremia.