The Symptoms of Chronic Nephritis

What are the symptoms of chronic nephritis? Chronic nephritis is a disease that comes on slowly. Chronic nephritis is mostly caused by some other diseases that are not treated in time. What are the symptoms of the chronic nephritis in clinical? They are mainly edema, hypertension, and urinary abnormalities. For the main clinical symptoms of chronic nephritis are mainly edema, hypertension and urinary abnormalities, all three can appear simultaneously or they can appear single or alternately. Detailed analysis is as follows:

The symptoms of chronic nephritis with hypertension:

Chronic nephritis patient is generally moderate hypertension, systolic pressure is at about 20 ~ 22.7kPa and diastolic pressure is at about 12.7 ~ 14kPa. Blood pressure can be effectively controlled, by taking diuretics and β-blockers such as propranolol,

The symptoms of edema in chronic nephritis:

Edema site often appears in the eyelids, face and legs, and usually is mild to moderate edema. When the chronic nephritis hasn’t caused uremia, it is rare to appear the symptoms of pleural effusion, ascites and so on.

The symptoms of chronic nephritis with urine abnormalities:

Moderate proteinuria: the certain quantity urine protein is about 2g /24-hour and is often non-selective proteinuria.

Gross hematuria or microscopic hematuria in urine is one of changing situation of chronic nephritis’ urine. Using phase contrast microscope to examine, more than 90% is the deformation of red cell hematuria and a small number of red cell is a homogeneous type of hematuria. Except for proteinuri and hematuria, there are still abnomalties of tube urine, urine volume changes, specific gravity and uosm urine osmotic pressure.

After understanding of the clinical symptoms of chronic nephritis, we have a look at why the chronic nephritis has stubborn sustained hypertension?

The symptoms of chronic nephritis - the reasons for high blood pressure

Possible reasons for the high blood pressure:

(1), when kidney has a disease, renal parenchyma is destructed. Renal anti-pressor substance is decreased. Some people think that renal hypertension may be associated with the decrease of renal anti-pressor substance formed by kidney. So we can make use of prostaglandin to treat hypertension, because prostate have a strong effects to bring high blood pressure down and improve renal blood flow volume.

2) When renal is ischemia, the rennin in blood is increased. Small artery spasm becomes serious and lead to persistent hypertension. At the same time, aldosterone’s secretion increase, which makes water-sodium retention and blood volume increase, so, the blood pressure will be further elevated.

(3) Systemic small artery spasm sclerosis: kidney with longer duration of hypertension may appear small systemic atherosclerosis and small artery resistance increased, to promote increase of blood pressure.